Specialized Immune Cells Help Our Skin Respond to Changing Environmental Conditions
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Summary
<img src="https://www.newswise.com/legacy/image.php?image=https://media.newswise.com/pio/articles/857591/6ae362511d234_Fuchs_102726_Hero_1_857591.png&width=100&height=150" alt="Newswise image" />Epidermal stem cells oversee the skin's ability to respond to stressors from the outside world and then return to a steady state. Researchers have discovered a circuit that regulates this normal flux that operates via Langerhans immune cells. The circuit acts like a rheostat that continuously fine tunes the stem cells' response to the environment at the skin surface, coordinating barrier integrity, antimicrobial peptide production, and host-microbe interactions.
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