New study of bacterial genome could lead to better TB drugs
· newswise.com · popularity 21/100 · 0 similar stories today · Future Technology, Innovation & Design (Discovery & Research)
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Summary
<img src="https://www.newswise.com/legacy/image.php?image=https://media.newswise.com/pio/articles/857941/6aeb3e834c9af_Rock_HERO_11226_857941.png&width=100&height=150" alt="Newswise image" />Rockefeller researchers created the first comprehensive map of interactions among genes essential to the survival of Mycobacterium tuberculosis, the bacterium responsible for tuberculosis. To enable the study, the team refined a CRISPRi-based platform they initially developed for tuning gene expression, extending it to support large-scale perturbation of gene pairs. Their platform has already revealed four new synergistic drug combinations and predicts dozens more, offering scientists a new path to combat antibiotic resistance.
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