Biomimetic nanoparticle combines antibacterial and regenerative actions for periodontitis
· newswise.com · popularity 17/100 · 0 similar stories today · Materials Science & Nanotechnology (Discovery & Research)
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Summary
<img src="https://www.newswise.com/legacy/image.php?image=https://media.newswise.com/pio/articles/858167/6af00df406897_22_858167.jpg&width=100&height=150" alt="Newswise image" />A biomimetic nanoparticle that combines antibacterial, immunomodulatory, and regenerative actions could offer a more comprehensive strategy for periodontitis. Researchers developed neutrophil-macrophage hybrid membrane-coated minocycline-loaded gelatin nanoparticles (NMm@MINO) and evaluated whether the platform could control periodontal pathogens, reprogram macrophages toward a repair-associated phenotype, and support periodontal tissue repair. The nanoparticle was designed for protease-responsive drug release and tested for bactericidal activity in vitro, macrophage polarization, osteogenesis, osteoclastogenesis, fibroblast function, as well as its therapeutic effects in a ligature-induced rat model. The work supports a multi-target local therapeutic approach that addresses infection, inflammation, and tissue destruction together rather than focusing on bacterial control alone.
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