Bone-Building Drugs Restore Jawbone Lost to Type 2 Diabetes in Mice
· newswise.com · popularity 20/100 · 0 similar stories today · Chronic Conditions (Health & Life Sciences)
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Summary
Researchers report that two FDA-approved bone anabolic agents, parathyroid hormone (PTH) and abaloparatide (ABL), can restore alveolar bone lost to type 2 diabetes (T2D) in mice. Unlike in non-diabetic animals, where the drugs stimulated both bone formation and resorption with no net gain, in diabetic mice they selectively boosted bone formation without further increasing the already elevated resorption, producing net bone gain. The work identifies osteocytes as the cellular mediators of this anabolic effect and points to a strategy for improving tooth retention and dental implant success in diabetic patients.
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